E-mail: paulo.caldas@tecnico.ulisboa.pt
Post-Doctoral Fellow, Faculdade de Ciencias e Tecnologia, Universidade NOVA de Lisboa, Portugal, 2021-2025
PhD in Biochemistry and Molecular Biology, Institute of Science and Technology, Austria, 2015-2020
MSc in Medical Biochemistry, Faculdade de Ciencias, Universidade de Lisboa, Portugal, 1989
Exploring the mechanisms of X-chromosome inactivation, gene expression, and epigenetic regulation in human health and disease. My work focuses on improving epigenetic fidelity in stem cell models and advancing their application in disease modeling. By integrating experimental and computational approaches, I aim to enhance our understanding of epigenetic control and improve the precision of stem cell-based models for human disease research..
Raposo, A. C.*, Caldas, P.*, Jeremias, J., Arez, M., Mateus, F. C., Barbosa, P., Sousa-Luís, R., Água, F., Oxley, D., Mupo, A., et al. Gene reactivation upon erosion of X chromosome inactivation in female hiPSCs is predictable yet variable and persists through differentiation. Stem Cell Reports, 20(5) (2025). *Equal Contribution
Caldas, P., Luz, M., Baseggio, S., Andrade, R., Sobral, D., & Grosso, A. R. Transcription readthrough is prevalent in healthy human tissues and associated with inherent genomic features. Communications Biology, 7(1), 100 (2024).
Caldas, P., Radler, P., Sommer, C., & Loose, M. Computational analysis of filament polymerization dynamics in cytoskeletal networks. In Methods in Cell Biology, 158, 145–161 (2020).
Caldas, P., López-Pelegrín, M., Pearce, D. J. G., Budanur, N. B., Brugués, J., & Loose, M. Cooperative ordering of treadmilling filaments in cytoskeletal networks of FtsZ and its crosslinker ZapA. Nature Communications, 10(1), 5744 (2019).
Complete list of publications can be seen at ORCID.