SCERG - IST

Vision

At the Bioelectronics for Cancer Therapies Lab we are committed at pushing the frontiers of cancer treatment through the integration of cutting-edge bioelectronics and bioengineer research.

Our lab is dedicated to developing innovative, non-invasive therapies that target cancer at its core, with a particular focus on using bioelectronic systems to enhance the precision, efficacy, and delivery of cancer treatments.

Research Focus

The lab’s research encompasses a wide range of interdisciplinary topics. Our current focus areas include:

1. Investigation of the bioelectrical process involved in cancer development and progression

Cells present bioelectrical activity through ionic and faradaic currents which play a key role in homeostasis. In cancer, these signals can become dysregulated, contributing to the uncontrolled growth and invasion of malignant cells. Our lab investigates how disruptions in the normal bioelectrical patterns of cells contribute to the initiation and progression of cancer. By understanding how altered electrical properties of cancer cells drive tumorigenesis, we can identify new therapeutic targets that allow us to manipulate these electrical signals and potentially halt or reverse the progression of cancer.

2. Develop bioelectronic systems with potential to interfere with cancer bioelectricity for a novel route of therapeutic intervention

The development of bioelectronic systems with the potential to interfere with cancer bioelectricity represents a novel, transformative approach to cancer therapy. These cutting-edge systems leverage bioelectricity to combat cancer in ways that traditional therapies cannot. By targeting the electrical properties of cancer cells, these bioelectronic interventions offer a potentially revolutionary method for stopping tumour growth, enhancing treatment efficacy, and reducing side effects. Additionally, these systems can use physical stimuli such as electrical pulses, heat, or mechanical forces to precisely release drugs and therapeutic compounds, further improving the targeted delivery and minimizing harm to healthy tissues

3. Manufacture advanced in vitro cancer models

The manufacture of advanced in vitro cancer models is a critical component of our lab's efforts to revolutionize cancer therapy. By providing a realistic and adaptable platform for studying cancer and testing bioelectronic interventions, these models are helping to pave the way for more effective, personalised cancer treatments. One of our key techniques is 3D bioprinting to fabricate complex tumour structures with precise control over cell placement and tissue architecture.

RESEARCH

Focus Area Devices and Materials Engineering for Sustainability and Health (dMESH)

Bioelectronics for Cancer Therapies

PI: Paola Alberte