The main goal is the design of novel scaffolds, devices and bioreactors to support stem cell 3D culture and biochemical-physical stimulation. A multidisciplinary approach combining stem cells, novel materials, devices and bioreactor engineering is envisioned, with the potential to impact and positively support significant advances on stem cell to organ engineering for disease modeling/drug discovery or clinical translation. iPSC and MSC are used on articulation with the other Focus Areas.