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The Stem Cell Engineering Research Group (SCERG) at iBB - Institute for Biosciences and Bioengineering of Instituto Superior Técnico, Universidade de Lisboa, Portugal aims at the development of cell production systems for the ex-vivo expansion of stem cells and/or their controlled differentiation into specific cell types, as well as their integration with bioseparation and high resolution purification technologies, to generate the large numbers of specific and high quality stem/progenitor cell subsets needed for Precision and Regenerative Medicine settings.




Encontro Ciência 2019

July 8-10, 2019

Lisbon, Portugal



Towards Cost-effective Stem Cell-based Therapies for Type 1 Diabetes

June 11, 2019

Type 1 diabetes is an auto-immune disease where patients need to monitor and take insulin daily. Transplantation of encapsulated islet cells is performed in some countries to restore glucose control, but shortage of donors is a major bottleneck. Devices with stem cell-derived beta cells are now in clinical trials. Researchers at SCERG-iBB and Harvard Medical School performed an early health technology assessment modeling study to simulate, based on bioprocess and disease progression modeling, the manufacturing costs of devices containing pluripotent stem cell (PSC)-derived beta cells. This information was combined with medical data to determine cost-effectiveness of the new therapy. The work was published in Biotechnology Journal.

Joana Serra

Joana Serra to Defend PhD Thesis in Bioengineering

June 3, 2019

Joana Serra will be defending her PhD thesis in Bioengineering at Instituto Superior Técnico, friday the 7th June 2019 (10:30 H, room Q4.41). During the last years, and under the supervision of Miguel Prazeres from BERG-iBB and Cláudia Lobato-Silva from SCERG-iBB, Joana focused her efforts on the genetic modification of mesenchymal stem/stromal cells with VEGF-coding minicircles to improve their therapeutic features in the context of ischemia. The title of her thesis is "Ex-vivo gene therapy to improve the regenerative features of human mesenchymal stem/stromal cells (MSC) in a model of limb.

Graduation Day

Design Principles for Pluripotent Stem Cell-Derived Organoid Engineering

April 23, 2019

Human morphogenesis is a complex process involving distinct microenvironmental and physical signals that are manipulated in space and time to give rise to complex tissues and organs. The development of organoids represents a novel way to modeling such complexity. Advances in the bioengineering field have allowed the manipulation of different components, including cellular and noncellular factors, to better mimic the natural microenvironment and generate better organoid models of human morphogenesis. In a paper published in Stem Cells International, a team of researchers from the Stem Cell Engineering Research Group (SCERG) at iBB in collaboration with the Institute of Molecular Medicine reviewed the bioengineering strategies used to control the initial state and spatiotemporal positioning of cells within organoids and, lastly, the growth and remodeling of multicellular aggregates to achieve mini organ-like structures.