E-mail: ana.fernandes@tecnico.ulisboa.pt
Post-Doctoral Fellow, Instituto Superior Técnico, University of Lisbon, Portugal, 2011-2016
PhD in Bioengineering, MIT Portugal Program, Instituto Superior Técnico, University of Lisbon, Portugal, 2011
MSc in Biotechnology (Biochemical Engineering), Instituto Superior Técnico, University of Lisbon, Portugal, 2007
Diploma in Biological Engineering, Instituto Superior Técnico, University of Lisbon, Portugal, 2005
My research addresses the development of efficient, scalable and cost-effective production processes for the large-scale ex-vivo expansion of human adult stem cells (namely hematopoietic and mesenchymal stem cells) in controlled bioreactors.
Mizukami, A., Neto, M.S.A., Moreira, F., Fernandes-Platzgummer, A., Huang, Y.-F., Milligan, W., Cabral, J.M.S., da Silva, C.L., Covas, D.T., Swiech, K. A fully-closed and automated hollow fiber bioreactor for clinical-grade manufacturing of human mesenchymal stem/stromal cells. Stem Cell Rev Rep 14(1):141-143 (2018).
de Soure, A.M., Fernandes-Platzgummer, A., Moreira, F., Lilaia, C., Liu, S.-H., Ku, C.-P., Huang, Y.-F., Milligan, W., Cabral, J.M.S., da Silva, C.L. Integrated culture platform based on a human platelet lysate supplement for the isolation and scalable manufacturing of umbilical cord matrix-derived mesenchymal stem/stromal cells. J Tissue Eng Regen Med 11(5):1630-1640 (2017).
de Soure, A.M., Fernandes-Platzgummer, A., da Silva, C.L., Cabral, J.M.S. Scalable microcarrier-based manufacturing of mesenchymal stem/stromal cells. J Biotechnol 236:88-109 (2016).
Mizukami, A. Fernandes-Platzgummer, A., Carmelo, J.G., Swiech, K., Covas, D.T., Cabral, J.M.S., da Silva, C.L. Stirred tank bioreactor culture combined with serum-/xenogeneic-free culture medium enables an efficient expansion of umbilical cord-derived mesenchymal stem/stromal cells. Biotechnol J 11:1048-1059 (2016).
Fernandes-Platzgummer, A., Diogo, M.M., Lobato da Silva, C., Cabral, J.M.S. Maximizing Mouse Embryonic Stem Cell Production in a Stirred Tank Reactor by Controlling Dissolved Oxygen Concentration and Continuous Perfusion Operation. Biochem Eng J 82:81-90 (2014).
dos Santos, F., Campbell, A., Fernandes-Platzgummer, A., Andrade, P.Z., Gimble, J.M., Wen, Y., Boucher, S., Vemuri, M.C., da Silva, C.L., Cabral, J.M. A xenogeneic-free bioreactor system for the clinical-scale expansion of human mesenchymal stem/stromal cells. Biotechnol Bioeng 111:1116-1127 (2014).
Fernandes-Platzgummer, A., Diogo, M.M., Baptista, R.P., da Silva, C.L., Cabral, J.M.S. Scale-up of mouse embryonic stem cell expansion in stirred bioreactors. Biotechnol Prog 27(5):1421-1432 (2011).