SCERG Banner

PhD Student

Education and Training

MSc in Biotechnology, Instituto Superior Técnico, University of Lisbon, Portugal, 2017

BSc in Cell and Molecular Biology, Faculty of Sciences and Technology, New University of Lisbon, Portugal, 2015

Research activities

The major goal of my research project is to develop a microscale high-throughput culture system that mimics the 3D cellular microenvironment unveiling the interactions between cells and soluble/immobilized factors. This platform will be used to identify the sole and/or synergistic effects of soluble and immobilized molecules towards expansion and differentiation of hPSC. Additionally, it is intended to provide a platform to perform high-throughput studies on the toxicity of small molecules towards differentiated progeny and evaluate different cellular sensitivities to pharmaceuticals according to patient specificity.

Selected publications

Gopal, S., Rodrigues, A.L., Dordick, J.S. Exploiting CRISPR Cas9 in Three-Dimensional Stem Cell Cultures to Model Disease. Front Bioeng Biotechnol 8:692 (2020).

Fernandes, C.S.M., Rodrigues, A.L., Alves, V.D., Fernandes, T.G., Pina, A.S., Roque, A.C.A. Natural Multimerization Rules the Performance of Affinity-Based Physical Hydrogels for Stem Cell Encapsulation and Differentiation. Biomacromolecules 21(8):3081-3091 (2020).

Rodrigues, A.L., Fernandes, T.G., Diogo, M.M., Cabral, J.M.S., Dordick, J.S. Advanced microtechnologies for high-throughtput screening in Engineering Strategies for Regenerative Medicine (T.G. Fernandes, M.M. Diogo & J.M.S. Cabral, Eds.), Elsevier, ISBN 9780128162217 (2020).

Rodrigues, A.L., Rodrigues, C.A.V., Gomes, A.R., Vieira, S.F., Badenes, S.M., Diogo, M.M., Cabral, J.M.S. Dissolvable Microcarriers Allow Scalable Expansion And Harvesting Of Human Induced Pluripotent Stem Cells Under Xeno‐Free Conditions. Biotechnol J 14(4):e1800461 (2019).