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PhD student

Education and Training

Research Assistant, Instituto Superior Técnico, University of Lisbon, Portugal, 2016-2017

MSc in Biological Engineering, Instituto Superior Técnico, University of Lisbon, Portugal, 2016

BSc in Biological Engineering, Instituto Superior Técnico, University of Lisbon, Portugal, 2014

Research activities

My research is focused on the study of organoid biology and process engineering strategies that will be combined to develop region specific brain organoids, mainly containing ventral and dorsal forebrain characteristic interneurons, from human induced pluripotent stem cells (hiPSCs). The main objective is to model neurodevelopmental disorders affecting multiple neuronal subtypes originated from forebrain sub-regions. In particular, this project will focus on Rett Syndrome (RTT). The results obtained will contribute to the characterization and understanding of RTT during the early stages of neural development, before disease inception, by recapitulating the complex human neurodevelopmental defects in RTT syndrome. Moreover, this platform may also constitute a promising tool for disease diagnosis as well as for testing potential therapeutic drugs.

Selected publications

Gomes, A.R., Fernandes, T.G., Vaz, S.H., Silva, T.P., Bekman, E.P., Xapelli, S., Duarte, S., Ghazvini, M., Gribnau, J., Muotri, A.R., Trujillo, C.A., Sebastião, A.M., Cabral, J.M.S., Diogo, M.M. Modeling Rett Syndrome With Human Patient-Specific Forebrain Organoids. Front Cell Dev Biol 8:610427 (2020).

Gomes, A.R., Sangani, N.B., Fernandes, T.G., Diogo, M.M., Curfs, L.M.G., Reutelingsperger, C.P. Extracellular Vesicles in CNS Developmental Disorders. Int J Mol Sci 21:9428 (2020).

Rodrigues, A.L., Rodrigues, C.A.V., Gomes, A.R., Vieira, S.F., Badenes, S.M., Diogo, M.M., Cabral, J.M.S. Dissolvable Microcarriers Allow Scalable Expansion And Harvesting Of Human Induced Pluripotent Stem Cells Under Xeno‐Free Conditions. Biotechnol J 14(4):e1800461 (2019).

Rodrigues, C.A.V., Branco, M., Nogueira, D.E.S., Silva, T.P., Gomes, A.R., Diogo, M.M., Cabral, J.M.S. Bioreactors for Human Pluripotent Stem Cell Expansion and Differentiation, in Bioreactors for Stem Cell Expansion and Differentiation, (J.M.S. Cabral & C. Lobato da Silva, Eds.), CRC Press, ISBN 9781498795906 (2018).