Post-Doctoral Fellow, Instituto Superior Técnico, University of Lisbon, Portugal, 2011-2016
PhD in Bioengineering, MIT Portugal Program, Instituto Superior Técnico, University of Lisbon, Portugal, 2011
MSc in Biological Engineering, Instituto Superior Técnico, University of Lisbon, Portugal, 2007
Diploma in Biological Engineering, Instituto Superior Técnico, University of Lisbon, Portugal, 2005
My research at SCERG focuses on the development and operation of bioreactor culture systems for the large-scale expansion and controlled differentiation of human Plutipotent Stem Cells (PSC), which are able of extensive self-renewal and can differentiate into virtually all cell types of the human body. PSC technology holds great potential for the development of regenerative medicine therapies and also for drug discovery. However, the success of these approaches is still limited by the difficulty to generate large quantities of cells. The goal of my research is the design of biporocesses for the generation of large numbers of PSC and PSC-derived cells maintaining biological functionality and safety in a reproducible manner
Rodrigues, C.A.V., Nogueira, D.E.S., Cabral, J.M.S. Next-Generation Stem Cell Expansion Technologies. Cell Gene Therapy Insights 4(8):791-804 (2018).
Rodrigues, A.L., Rodrigues, C.A.V., Gomes, A.R., Vieira, S.F., Badenes, S.M., Diogo, M.M., Cabral, J.M.S. Dissolvable Microcarriers Allow Scalable Expansion And Harvesting Of Human Induced Pluripotent Stem Cells Under Xeno‐Free Conditions. Biotechnol J doi:10.1002/biot.201800461 [Epub ahead of print] (2018).
Rodrigues, C.A.V., Silva, T.P., Nogueira, D.E.S., Fernandes, T.G., Hashimura, Y., Wesselschmidt, R., Diogo, M.M., Lee, B., Cabral, J.M.S. Scalable Culture Of Human Induced Pluripotent Cells On Microcarriers Under Xeno‐Free Conditions Using Single‐Use Vertical‐Wheel™ Bioreactors. J Chem Technol Biotechnol 93(12):3597-3606 (2018).
Badenes, S.M., Fernandes, T.G., Miranda, C.C., Pusch-Klein, A., Haupt, S., Rodrigues, C.A.V., Diogo, M.M., Brüstle, O., Cabral, J.M.S. Long-term expansion of human induced pluripotent stem cells in a microcarrier-based dynamic system. J Chem Technol Biotechnol 92:492–503 (2017).
Badenes, S.M., Fernandes, T.G., Rodrigues, C.A.V., Diogo, M.M., Cabral, J.M.S. Microcarrier-based platforms for in vitro expansion and differentiation of human pluripotent stem cells in bioreactor culture systems. J Biotechnol 234:71-82 (2016).
Pires, F., Ferreira, Q., Rodrigues, C.A.V., Morgado, J., Ferreira, F.C. Neural stem cells differentiation by electrical stimulation using a cross-linked PEDOT substrate: expanding the use of biocompatible conjugated conductive polymers for neural tissue engineering. BBA-Gen Subjects 1850:1158-1168 (2015).
