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PhD student

Education and Training

MSc in Cellular and Molecular Biology (Neurobiology), Faculty of Science and Technology, University of Coimbra, Portugal, 2016

BSc in Biomedical Sciences, Department of Biomedical Sciences and Medicine, University of Algarve, Portugal, 2014

Research activities

My research is focused on the optimization of a protocol developed in our group that allows efficient generation of cerebellar organoids from human induced pluripotent stem cells (iPSCs), including the derivation of functionally mature cerebellar neurons, in order to study cerebellar ataxias, such as Angelman Syndrome. Thus, generation of 3D cerebellar organoids derived from Angelman Syndrome patients will be crucial to contribute towards a better understanding of the molecular mechanisms that regulate cerebellar development and dysfunction in disease.

Selected publications

Maranga, C., Fernandes, T.G., Bekman, E., da Rocha, S.T. Angelman syndrome: a journey through the brain. FEBS J 287(11):2154-2175 (2020).