Research Assistant, 3B's Research Group, University of Minho, Portugal, 2014-2015
MSc in Biomedical Engineering, Instituto Superior Técnico, University of Lisbon, Portugal, 2013
BSc in Biomedical Engineering, Instituto Superior Técnico, University of Lisbon, Portugal, 2011
My research work is focused in the development of a new platform comprising 3D hierarchical scaffolds, mesenchymal stem/stromal cells (MSC) and bioreactor prototypes for the production of native-like articular cartilage. This project will employ the use of different biomanufacturing techniques such as extrusion, hydrogel synthesis and electrospinning to produce scaffolds able to mimic the complex stratified architecture of articular cartilage with different mechanical properties, extracellular matrix (ECM) composition and cell organization according with tissue location. Glycosaminoglycans (GAGs) known to have a role in the chondrogenic process will be studied and further incorporated within the scaffold structure. In addition, bioreactor prototypes able to provide different biophysical stimuli such as mechanical compressive loading and shear stress to promote chondrogenesis will be developed. We believe that our integrated strategy will play an important role in defining the optimal conditions for articular cartilage tissue engineering strategies.
Aroso, I.M, Silva, J.C, Mano, F., Sá-Nogueira, I., Barreiros, S., Reis, R.L., Paiva, A., Duarte, A.R.C. Dissolution enhancement of active pharmaceutical ingredients by therapeutic deep eutectic systems. Eur J Pharm Biopharm 98:57-66 (2016).
Silva, J.C, Barros, A.A., Aroso, I.M., Fassini, D., Silva, T.H., Reis, R.L., Duarte, A.R.C. Extraction of Collagen/Gelatin from Marine Demosponge Chondrosia reniformis (Nardo, 1847) using Water Acidified with Carbon Dioxide – Process Optimization. Ind Eng Chem Res 55(25):6922-6930 (2016).
Silva, J.C, Moura, C.S., Alves, N.M., Cabral, J.M.S., Ferreira, F.C. Effects of different fibre alignments and bioactive coatings on mesenchymal stem/stromal cell adhesion and proliferation in poly(ε-caprolactone) scaffolds towards cartilage repair. Procedia Manuf 12:132-140 (2017).
