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Assistant Professor

Education and Training

Research Scientist, Institute for Biotechnology and Bioengineering (IBB), Instituto Superior Técnico, University of Lisbon, Portugal, 2008-2013

Post-Doctoral Fellow, Bioengineering Research Group (BERG), Instituto Superior Técnico, University of Lisbon, Portugal, 2004-2008

PhD in Biotechnology, Instituto Superior Técnico, University of Lisbon, Portugal, 2004

MSc in Biotechnology (Biochemical Engineering), Instituto Superior Técnico, University of Lisbon, Portugal, 1999

Diploma in Industrial Chemistry, University of Beira Interior, Portugal, 1997

Research activities

My current research activities are focused on the development of innovative advanced models of healthy and diseased human tissues from induced pluripotent stem cells (hiPSCs) and their applications for personalized medicine in particular for disease modelling and for the development of drug screening and toxicology assays. Presently ongoing projects include the development of region-specific brain organoids and assembloids from patient-specific hiPSCs for modelling neurodevelopmental diseases and drug screening and the engineering of novel heart organoids for cardiotoxicology assays.

Selected publications

Gomes, A.R., Fernandes, T.G., Vaz, S.H., Silva, T.P., Bekman, E.P., Xapelli, S., Duarte, S., Ghazvini, M., Gribnau, J., Muotri, A.R., Trujillo, C.A., Sebastião, A.M., Cabral, J.M.S., Diogo, M.M. Modeling Rett Syndrome With Human Patient-Specific Forebrain Organoids. Front Cell Dev Biol 8:610427 (2020).

Branco, M.A., Cabral, J.M.S., Diogo, M.M. From Human Pluripotent Stem Cells to 3D Cardiac Microtissues: Progress, Applications and Challenges. Bioengineering 7(3):92 (2020).

Silva, T.P., Bekman, E., Fernandes, T.G., Vaz, S.H., Rodrigues, C.A.V., Diogo, M.M., Cabral J.M.S., Carmo-Fonseca, M. Maturation of human pluripotent stem cell-derived cerebellar neurons in the absence of co-culture. Front Bioeng Biotechnol 8:70 (2020).

Branco, M.A., Cotovio, J.P., Rodrigues, C.A.V., Vaz, S.H., Fernandes, T.G., Moreira, L.M., Cabral, J.M.S., Diogo, M.M. Transcriptomic analysis of 3D Cardiac Differentiation of Human Induced Pluripotent Stem Cells Reveals Faster Cardiomyocyte Maturation Compared to 2D Culture. Sci Rep 9:9229 (2019).

Rodrigues, A.L., Rodrigues, C.A.V., Gomes, A.R., Vieira, S.F., Badenes, S.M., Diogo, M.M., Cabral, J.M.S. Dissolvable Microcarriers Allow Scalable Expansion And Harvesting Of Human Induced Pluripotent Stem Cells Under Xeno‐Free Conditions. Biotechnol J 14(4):e1800461 (2019).

Miranda, C.C., Fernandes, T.G., Pinto, S.N., Prieto, M., Diogo, M.M., Cabral, J.M.S. A scale out approach towards neural induction of human induced pluripotent stem cells for neurodevelopmental toxicity studies. Toxicol Lett 294:51-60 (2018).

Dias, T.P., Pinto, S.N., Santos, J.I., Fernandes, T.G., Fernandes, F., Diogo, M.M., Prieto, M., Cabral, J.M.S. Biophysical study of human induced Pluripotent Stem Cell-Derived cardiomyocyte structural maturation during long-term culture. Biochem Biophys Res Commun 499(3):611-617 (2018).

Rodrigues, G.M.C., Gaj, T., Adil, M.M., Wahba, J., Rao, A.T., Lorbeer, F.K., Kulkarni, R.U., Diogo M.M., Cabral, J.M.S., Miller, E.W., Hockemeyer, D., Schaffer, D.V. Defined and Scalable Differentiation of Human Oligodendrocyte Precursors from Pluripotent Stem Cells in a 3D Culture System. Stem Cell Rep 8(6):1770-1783 (2017).

Badenes, S.M., Fernandes, T.G., Cordeiro, C.S.M., Boucher, S., Kuninger, D., Vemuri, M.C., Diogo, M.M., Cabral, J.M.S. Defined essential 8™ medium and vitronectin efficiently support scalable xeno-free expansion of human induced pluripotent stem cells in stirred microcarrier culture systems. PLoS One 11:e0151264 (2016).

Fernandes, T.G., Duarte, S.T., Ghazvini, M., Gaspar, C., Santos, D.C., Porteira, A.R., Rodrigues, G.M.C., Haupt, S., Rombo, D.M., Armstrong, J., Sebastião, A.M., Gribnau, J., Garcia-Cazorla, A., Brüstle, O., Henrique, D., Cabral, J.M.S., Diogo, M.M. Neural commitment of human pluripotent stem cells under defined conditions recapitulates neural development and generates patient-specific neural cells. Biotechnol J 10(10):1587-1588 (2015).

Miranda, C.M., Fernandes, T.G., Pascoal, J.F., Haupt, S., Brüstle, O., Cabral, J.M.S., Diogo, M.M. Spatial and temporal control of cell aggregation efficiently directs human pluripotent stem cells towards neural commitment. Biotechnol J 10(10):1612-1624 (2015).