Postdoctoral researcher, Instituto de Medicina Molecular, University of Lisbon, Portugal, 2019-2021
Postgraduate in Clinical Neuropshycology , Instituto Português de Psicologia, Portugal, 2019
Postdoctoral researcher, Universitá Statale di Milano, Italy, 2017-2018
Postdoctoral researcher, Boston University School of Medicine, USA, 2016-2017
PhD in Biomedicine (Behavioral, Molecular and Pharmacology Neuroscience), Biomedical Research Park of Barcelona, University Pompeu Fabra, Spain, 2016
MSc in Pharmacy and Industrial Pharmacy, Universitá degli Studi di Siena, Italy; University Autonoma of Barcelona, Spain; 2010
Aging-specific epigenetic drift has been mostly studied at the level of DNA methylation, where consistent changes in 5-methycytosine levels at several genomic regions have been noticed. DNA methylation is a common mechanism regulating monoallelic expression of different genes, including imprinted genes expressed in a parent-of-origin-specific manner. How age-related alterations of methylation levels varies across alleles and impact on monoallelic expression is not known. In the brain, this phenomenon may contribute mechanistically to neuronal dysfunction and diseases.
My research work focuses to investigate the allele-specific transcriptional and epigenetic signatures of aging in the brain and the functional consequences by the use of IPSC technology, thus providing the proof-of-concept of the feasibility of epigenetic modulation as strategy to be applied in the context of neuro-regenerative therapies.
Mancino, S., Boraso, M., Galmozzi, A., Marinovich, M., Crestani, M., Viviani, B. Dualistic SAHA dose-dependent effects on glial-inflammatory response: a microarrey comparative study. BioRxiv, preprint server (2021).
Mancino, S., Serafini, M.M, Viviani, B. Neuron-Glia Interactions Studied with In Vitro Co-Cultures. in Cell Culture Techniques (M. Aschner & L. Costa, Eds.), Humana, ISBN 9781493992287 (2019).
Moore, C., Schlain, G., Mancino, S., Sabino, V., Cottone, P. A behavioral and pharmacological characterization of Palatable Diet Alternation in Mice. Pharmacol Biochem Behav 163:1-8 (2017).
Mancino, S., Netto, S., Martin-Garcia, E., Maldonado, R. Role of DOR in neuronal plasticity changes promoted by by food-seeking behaviour. Addict Biol 22(5):1179-1190 (2017).
Mancino, S., Burokas, A., Gutiérrez-Cuesta, J., Gutiérrez-Martos, M., Martín-García, E., Pucci, M., Falcone, A., D'Addario, C., Maccarrone, M., Maldonado, R. Epigenetic and Proteomic Expression Changes Promoted by eating addictive-like behavior. Neuropsychopharmacology 40(12):2788-2800 (2015).
Gutiérrez-Cuesta, J., Burokas, A., Mancino, S., Kummer, S., Martín-García, E., Maldonado, R. Effects of Genetic Deletion of Endogenous Opioid System Components on the Reinstatement of Cocaine-Seeking Behavior in Mice. Neuropsychopharmacology 39(13):2974-2988 (2014).